Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

Author:

Vidadala Rama Subba Rao1,Rivas Kasey L.2,Ojo Kayode K.2,Hulverson Matthew A.2,Zambriski Jennifer A.3,Bruzual Igor4,Schultz Tracey L.5,Huang Wenlin6,Zhang Zhongsheng6,Scheele Suzanne7,DeRocher Amy E.7,Choi Ryan2,Barrett Lynn K.2,Siddaramaiah Latha Kallur6,Hol Wim G. J.6,Fan Erkang6,Merritt Ethan A.6,Parsons Marilyn78,Freiberg Gail9,Marsh Kennan9,Kempf Dale J.9,Carruthers Vern B.5,Isoherranen Nina10,Doggett J. Stone4,Van Voorhis Wesley C.28,Maly Dustin J.61

Affiliation:

1. Department of Chemistry, University of Washington, Seattle, Washington 98195, United States

2. Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington 98109, United States

3. Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164, United States

4. Portland VA Medical Center, Portland, Oregon 97239, United States

5. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States

6. Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States

7. Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States

8. Department of Global Health, University of Washington, Seattle, Washington 98195, United States

9. AbbVie, North Chicago, Illinois 60064, United States

10. Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, United States

Funder

National Institute of Allergy and Infectious Diseases

National Institute of Child Health and Human Development

Stanley Medical Research Institute

Biomedical Laboratory Research and Development, VA Office of Research and Development

National Institute of General Medical Sciences

U.S. Department of Agriculture

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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