Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives-Reference-Cited by-同舟云学术

Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives

Published:2017-08-02 Issue:16 Volume:60 Page:6828-6852
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Hao¹^ORCID,Wu Guozhen¹,Gao Shuang¹,Guo Ruihua¹,Zhao Zeng¹,Yuan Hu²,Liu Shanxiang¹,Wu Jian³,Lu Xiaolong⁴,Yuan Xing¹,Yu Zongmin¹,Zu Xianpeng¹,Xie Ning⁵,Yang Niao¹,Hu Zhenlin¹,Sun Qingyan²,Zhang Weidong¹²⁶

Affiliation:

1. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China

3. Progenra, Inc., 277 Great Valley Parkway, Malvern, Pennsylvania 19355, United States

4. Lifesensors, Inc., 271 Great Valley Parkway, Malvern, Pennsylvania 19355, United States

5. State Key Laboratory of Innovative Natural Medicine and TCM Injections, Jiangxi Qingfeng Pharmaceutical Co., Ltd., Ganzhou 341000, Jiangxi, China

6. Institute of Interdisciplinary Research Complex, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China

Funder

Ministry of Science and Technology of the People's Republic of China

Changjiang Scholar Program of Chinese Ministry of Education

National Natural Science Foundation of China

Scientific Foundation of Shanghai

Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products

State Key Laboratory of Innovative Natural Medicine and TCM Injections

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01829

Reference54 articles.

1. The Use of Chimeric Vimentin Citrullinated Peptides for the Diagnosis of Rheumatoid Arthritis

2. Genetic susceptibility to rheumatoid arthritis and its implications for novel drug discovery

3. Drug survival, efficacy and toxicity of monotherapy with a fully human anti-tumour necrosis factor-alpha antibody compared with methotrexate in long-standing rheumatoid arthritis

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5. Drug-specific risk of tuberculosis in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the British Society for Rheumatology Biologics Register (BSRBR)

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