Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen-Reference-Cited by-同舟云学术

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Published:2016-12-22 Issue:1 Volume:60 Page:180-201
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cheeseman Matthew D.¹,Chessum Nicola E. A.¹,Rye Carl S.¹,Pasqua A. Elisa¹,Tucker Michael J.¹,Wilding Birgit¹^ORCID,Evans Lindsay E.¹,Lepri Susan¹,Richards Meirion¹,Sharp Swee Y.¹,Ali Salyha¹²,Rowlands Martin¹,O’Fee Lisa¹,Miah Asadh¹,Hayes Angela¹,Henley Alan T.¹,Powers Marissa¹,te Poele Robert¹,De Billy Emmanuel¹,Pellegrino Loredana¹,Raynaud Florence¹,Burke Rosemary¹,van Montfort Rob L. M.¹²,Eccles Suzanne A.¹,Workman Paul¹,Jones Keith¹^ORCID

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research, London SW7 3RP, United Kingdom

2. Division of Structural Biology at The Institute of Cancer Research, London SW7 3RP, United Kingdom

Funder

Cancer Research UK

Royal Marsden NHS Foundation Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01055