Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain-Reference-Cited by-同舟云学术

Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain

Published:2016-12-06 Issue:24 Volume:59 Page:11110-11119
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tamborini Lucia¹,Chen Ying²,Foss Catherine A.²,Pinto Andrea¹,Horti Andrew G.²,Traynelis Stephen F.³,De Micheli Carlo¹,Mease Ronnie C.²,Hansen Kasper B.⁴,Conti Paola¹^ORCID,Pomper Martin G.²

Affiliation:

1. Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy

2. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, Maryland 21287, United States

3. Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States;

4. Department of Biomedical & Pharmaceutical Sciences, University of Montana, 32 Campus Drive, Missoula, Montana 59812, United States

Funder

National Institute of Neurological Disorders and Stroke

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01344

Reference26 articles.

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4. Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors

5. N′-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N′-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl-d-aspartate (NMDA) Receptor: Synthesis and Structure–Affinity Relationships

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