Ugi Reaction-Derived α-Acyl Aminocarboxamides Bind to Phosphatidylinositol 3-Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells-Reference-Cited by-同舟云学术

Ugi Reaction-Derived α-Acyl Aminocarboxamides Bind to Phosphatidylinositol 3-Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells

Published:2017-05-08 Issue:10 Volume:60 Page:4147-4160
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bach Matthias¹,Lehmann Anna²,Brünnert Daniela³,Vanselow Jens T.¹,Hartung Andreas²,Bargou Ralf C.⁴,Holzgrabe Ulrike²^ORCID,Schlosser Andreas¹,Chatterjee Manik³

Affiliation:

1. Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Josef-Schneider-Straße 2, 97080 Würzburg, Germany

2. Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany

3. Department of Internal Medicine II, Translational Oncology, University Hospital of Würzburg, Versbacher Straße 5, 97078 Würzburg, Germany

4. Comprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Versbacher Straße 5, 97080 Würzburg, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01613

Reference57 articles.

1. Role of the Major Heat Shock Proteins as Molecular Chaperones

2. HSF1, A Versatile Factor in Tumorogenesis

3. Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

4. Heat shock proteins in cancer: chaperones of tumorigenesis

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