Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery-Reference-Cited by-同舟云学术

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Published:2016-04-12 Issue:8 Volume:59 Page:3991-4006
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Davies Thomas G.¹,Wixted William E.²,Coyle Joseph E.¹,Griffiths-Jones Charlotte¹,Hearn Keisha¹,McMenamin Rachel¹,Norton David¹,Rich Sharna J.¹,Richardson Caroline¹,Saxty Gordon¹,Willems Henriëtte M. G.¹,Woolford Alison J.-A.¹,Cottom Joshua E.³,Kou Jen-Pyng²,Yonchuk John G.²,Feldser Heidi G.²,Sanchez Yolanda²,Foley Joseph P.²,Bolognese Brian J.²,Logan Gregory²,Podolin Patricia L.²,Yan Hongxing²,Callahan James F.²,Heightman Tom D.¹,Kerns Jeffrey K.²

Affiliation:

1. Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.

2. GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

3. GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00228

Reference52 articles.

1. An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements