Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window-Reference-Cited by-同舟云学术

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Published:2016-05-24 Issue:11 Volume:59 Page:5520-5541
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rudolph Joachim,Murray Lesley J.,Ndubaku Chudi O.,O’Brien Thomas,Blackwood Elizabeth,Wang Weiru,Aliagas Ignacio,Gazzard Lewis,Crawford James J.,Drobnick Joy,Lee Wendy,Zhao Xianrui,Hoeflich Klaus P.,Favor David A.¹,Dong Ping¹,Zhang Haiming,Heise Christopher E.,Oh Angela,Ong Christy C.,La Hank,Chakravarty Paroma,Chan Connie,Jakubiak Diana,Epler Jennifer,Ramaswamy Sreemathy,Vega Roxanne,Cain Gary,Diaz Dolores,Zhong Yu

Affiliation:

1. Shanghai Chempartner Inc., 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, People’s Republic of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00638

Reference28 articles.

1. PAK signalling during the development and progression of cancer

2. Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

3. Inhibitors of p21-Activated Kinases (PAKs)