Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies-Reference-Cited by-同舟云学术

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

Published:2017-01-18 Issue:3 Volume:60 Page:1018-1040
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nagase Hiroshi¹²^ORCID,Yamamoto Naoshi¹,Yata Masahiro²,Ohrui Sayaka¹,Okada Takahiro²,Saitoh Tsuyoshi¹,Kutsumura Noriki¹^ORCID,Nagumo Yasuyuki¹,Irukayama-Tomobe Yoko¹,Ishikawa Yukiko¹,Ogawa Yasuhiro¹,Hirayama Shigeto³,Kuroda Daisuke⁴,Watanabe Yurie⁴,Gouda Hiroaki⁴,Yanagisawa Masashi¹

Affiliation:

1. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan

2. Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan

3. Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

4. School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Society for the Promotion of Science

Toray Industries

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01418

Reference88 articles.

1. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

2. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

3. The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

4. Narcolepsy in orexin Knockout Mice

5. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

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