A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors-Reference-Cited by-同舟云学术

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A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors

Published:2017-01-03 Issue:1 Volume:60 Page:157-169
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Teuscher Kevin B.¹²,Zhang Min¹,Ji Haitao¹³²^ORCID

Affiliation:

1. Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612-9416, United States

2. Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, United States

3. Department of Oncologic Sciences, University of South Florida College of Medicine, Tampa, Florida 33612, United States

Funder

Congressionally Directed Medical Research Programs

Susan G. Komen

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00923

Reference40 articles.

1. The promise and peril of chemical probes

2. Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

3. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

4. Target validation using chemical probes

5. Intracellular drug concentration and disposition – The missing link?

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