A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation
Author:
Affiliation:
1. Department of Therapeutic Discovery−Discovery Technologies, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01781
Reference23 articles.
1. Small-Molecule PROTACS: New Approaches to Protein Degradation
2. Induced protein degradation: an emerging drug discovery paradigm
3. New insights into ubiquitin E3 ligase mechanism
4. Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells
5. Catalytic in vivo protein knockdown by small-molecule PROTACs
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