A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation-Reference-Cited by-同舟云学术

A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation

Published:2017-04-17 Issue:2 Volume:61 Page:453-461
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wurz Ryan P.^ORCID,Dellamaggiore Ken,Dou Hannah¹,Javier Noelle¹,Lo Mei-Chu¹,McCarter John D.,Mohl Dane,Sastri Christine,Lipford J. Russell,Cee Victor J.

Affiliation:

1. Department of Therapeutic Discovery−Discovery Technologies, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01781

Reference23 articles.

1. Small-Molecule PROTACS: New Approaches to Protein Degradation

2. Induced protein degradation: an emerging drug discovery paradigm

3. New insights into ubiquitin E3 ligase mechanism

4. Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells

5. Catalytic in vivo protein knockdown by small-molecule PROTACs

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