Discovery of Novel Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2

Discovery of Novel Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

Published:2016-11-15 Issue:22 Volume:59 Page:10147-10162
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gollner Andreas¹,Rudolph Dorothea¹,Arnhof Heribert¹,Bauer Markus¹,Blake Sophia M.¹,Boehmelt Guido¹,Cockroft Xiao-Ling¹,Dahmann Georg²,Ettmayer Peter¹,Gerstberger Thomas¹,Karolyi-Oezguer Jale¹,Kessler Dirk¹,Kofink Christiane¹,Ramharter Juergen¹,Rinnenthal Jörg¹,Savchenko Alexander¹,Schnitzer Renate¹,Weinstabl Harald¹,Weyer-Czernilofsky Ulrike¹,Wunberg Tobias¹,McConnell Darryl B.¹

Affiliation:

1. Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer-Gasse 5-11, A-1121 Vienna, Austria

2. Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany

Funder

Österreichische Forschungsförderungsgesellschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00900

Reference69 articles.