Synthesis and Characterization of Urofuranoic Acids: In Vivo Metabolism of 2-(2-Carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic Acid (CMPF) and Effects on in Vitro Insulin Secretion
Author:
Affiliation:
1. Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States
2. Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Funder
Canadian Institutes of Health Research
Banting and Best Diabetes Centre, University of Toronto
Division of Graduate Education
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01668
Reference36 articles.
1. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014;Centers for Disease Control and Prevention, 2014.
2. Prevalence Estimates of Gestational Diabetes Mellitus in the United States, Pregnancy Risk Assessment Monitoring System (PRAMS), 2007–2010
3. Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development
4. The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction
5. CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome
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