Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells-Reference-Cited by-同舟云学术

Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells

Published:2016-06-07 Issue:12 Volume:59 Page:5752-5765
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Devambatla Ravi Kumar Vyas¹,Namjoshi Ojas A.¹,Choudhary Shruti¹,Hamel Ernest²,Shaffer Corena V.³,Rohena Cristina C.³,Mooberry Susan L.³,Gangjee Aleem¹

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States

2. Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, United States

3. Department of Pharmacology, Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, United States

Funder

National Cancer Institute

University of Texas Health Science Center at San Antonio

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00237

Reference51 articles.

1. Microtubule-binding agents: a dynamic field of cancer therapeutics

2. Microtubule dynamics as a target in oncology