Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors-Reference-Cited by-同舟云学术

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

Published:2017-03-02 Issue:9 Volume:60 Page:3594-3605
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cernak Tim¹^ORCID,Gesmundo Nathan J.¹,Dykstra Kevin¹,Yu Yang¹,Wu Zhicai¹,Shi Zhi-Cai¹,Vachal Petr¹,Sperbeck Donald¹,He Shuwen¹,Murphy Beth Ann¹,Sonatore Lisa¹,Williams Steven¹,Madeira Maria¹,Verras Andreas¹,Reiter Maud¹,Lee Claire Heechoon¹,Cuff James¹,Sherer Edward C.¹^ORCID,Kuethe Jeffrey¹,Goble Stephen¹,Perrotto Nicholas¹,Pinto Shirly¹,Shen Dong-Ming¹,Nargund Ravi¹,Balkovec James¹,DeVita Robert J.¹,Dreher Spencer D.¹

Affiliation:

1. Department of Discovery Chemistry, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Funder

Merck

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01543

Reference51 articles.

1. Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle