1. Faculty
of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan
2. Department
of Pharmacology, Juntendo University School of Medicine, Hongo, Bunkyo-ku,
Tokyo 113-8421, Japan
3. Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koutou-ku, Tokyo 135-0064, Japan
4. Center
for Research and Education on Drug Discovery, Hokkaido University, Kita-ku,
Sapporo 060-0812, Japan