Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme-Reference-Cited by-同舟云学术

Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme

Published:2016-05-18 Issue:11 Volume:59 Page:5471-5487
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Prado Verónica¹,Lence Emilio¹,Maneiro María¹,Vázquez-Ucha Juan C.²,Beceiro Alejandro²,Thompson Paul³,Hawkins Alastair R.³,González-Bello Concepción¹

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, calle Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain

2. Servicio de Microbioloxía-INIBIC, Complexo Hospitalario Universitario A Coruña (CHUAC), 15006 A Coruña, Spain

3. Institute of Cell and Molecular Biosciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, U.K.

Funder

Ministerio de Economía y Competitividad

Ministerio de Educación, Cultura y Deporte

Instituto de Salud Carlos III

Xunta de Galicia

European Regional Development Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00483

Reference47 articles.

1. The antibiotic resistome: the nexus of chemical and genetic diversity

2. Investigational Agents for the Treatment of Gram-Negative Bacterial Infections: A Reality Check

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