Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies

Author:

Dampalla Chamandi S.1ORCID,Rathnayake Athri D.1ORCID,Perera Krishani Dinali2ORCID,Jesri Abdul-Rahman M.1,Nguyen Harry Nhat1,Miller Matthew J.1,Thurman Hayden A.1,Zheng Jian3,Kashipathy Maithri M.4,Battaile Kevin P.5ORCID,Lovell Scott4,Perlman Stanley3,Kim Yunjeong2,Groutas William C.1ORCID,Chang Kyeong-Ok2

Affiliation:

1. Department of Chemistry, Wichita State University, Wichita, Kansas 67260, United States

2. Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, United States

3. Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, United States

4. Protein Structure Laboratory, The University of Kansas, Lawrence, Kansas 66047, United States

5. NYX, New York Structural Biology Center, Upton, New York 11973, United States

Funder

Foundation for the National Institutes of Health

Office of Science

U.S. Department of Energy

National Institute of General Medical Sciences

National Science Foundation

Hauptman-Woodward Medical Research Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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