Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure–Activity Relationship and In Vivo Oral Efficacy Studies-Reference-Cited by-同舟云学术

Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure–Activity Relationship and In Vivo Oral Efficacy Studies

Published:2021-04-12 Issue:8 Volume:64 Page:5198-5215
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dziwornu Godwin Akpeko¹,Coertzen Dina²,Leshabane Meta²,Korkor Constance M.¹^ORCID,Cloete Cleavon K.¹,Njoroge Mathew³,Gibhard Liezl³,Lawrence Nina³,Reader Janette²,van der Watt Mariëtte²,Wittlin Sergio⁴⁵,Birkholtz Lyn-Marie²^ORCID,Chibale Kelly¹⁶⁷^ORCID

Affiliation:

1. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

2. Department of Biochemistry, Genetics and Microbiology, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa

3. Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa

4. Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4002, Switzerland

5. University of Basel, Basel 4003, Switzerland

6. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

7. South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch 7701, South Africa

Funder

National Research Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00354