Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ-Reference-Cited by-同舟云学术

Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ

Published:2021-08-12 Issue:16 Volume:64 Page:12304-12321
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bellenie Benjamin R¹^ORCID,Hall Edward²,Bruce Ian¹,Spendiff Matthew¹,Culshaw Andrew¹,McDonald Sarah¹,Ambarkhane Ameet¹,Chinn Colin¹,Thomas Matthew¹,Rosner Elisabeth¹,Bracher Marguerite¹,Nicklin Paul¹,Marshall Stephen¹,Coote Julie¹,Cullen Eva¹,Tessier Clemence³,Wuersch Kuno³,Lal Ajay²,Wallis Gillian¹,Hollingworth Gregory J.³,Neef James²^ORCID

Affiliation:

1. Novartis Institutes for Biomedical Research, Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.

2. Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

3. Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00986

Reference41 articles.

1. The Phosphoinositide 3-Kinase Pathway