Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i)
Author:
Affiliation:
1. Merck KGaA, Frankfurter Str. 250, Darmstadt 64293, Germany
2. Syngene International Limited, Biocon Park, Plot2&3, Bommasandra-Jigani Link Road, Bangalore 560 099, India
Funder
Pharmaron Beijing Co., Ltd.
Lead Discovery Center GmbH
Proteros Biostructures GmbH
Syngene International Ltd
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00604
Reference52 articles.
1. Peptide-Based Proteasome Inhibitors in Anticancer Drug Design
2. Proteasomes in immune cells: more than peptide producers?
3. The Immunoproteasome as a Therapeutic Target for Hematological Malignancies
4. Effects of PS-341 on the Activity and Composition of Proteasomes in Multiple Myeloma Cells
5. Isolation and Characterization of Bovine Thymus Multicatalytic Proteinase Complex
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