Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 <i>In Vivo</i>-Reference-Cited by-同舟云学术

Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo

Published:2022-06-02 Issue:12 Volume:65 Page:8191-8207
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huckvale Rosemary¹,Harnden Alice C.¹^ORCID,Cheung Kwai-Ming J.¹,Pierrat Olivier A.¹,Talbot Rachel¹,Box Gary M.¹,Henley Alan T.¹,de Haven Brandon Alexis K.¹,Hallsworth Albert E.¹,Bright Michael D.¹,Akpinar Hafize Aysin¹,Miller Daniel S. J.¹,Tarantino Dalia¹,Gowan Sharon¹,Hayes Angela¹,Gunnell Emma A.¹²,Brennan Alfie¹,Davis Owen A.¹,Johnson Louise D.¹,de Klerk Selby¹,McAndrew Craig¹,Le Bihan Yann-Vaï¹²^ORCID,Meniconi Mirco¹^ORCID,Burke Rosemary¹,Kirkin Vladimir¹,van Montfort Rob L. M.¹²,Raynaud Florence I.¹^ORCID,Rossanese Olivia W.¹,Bellenie Benjamin R.¹^ORCID,Hoelder Swen¹^ORCID

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.

2. Division of Structural Biology, The Institute of Cancer Research, London SM2 5NG, U.K.

Funder

Cancer Research UK

Sixth Element Capital

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02175