Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic-Reference-Cited by-同舟云学术

Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic

Published:2021-06-21 Issue:13 Volume:64 Page:9458-9483
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Huoming¹,Li Xueping²³,Xie Peng¹,Li Xinwei¹,Xu XueJun²,Qian Yuanyuan¹,Yuan Congmin¹,Meng Xiangguo⁴,Chai JingRui²,Chen Jing²,Liu Jing²³,Wang Wenli¹,Li Wei¹,Wang YuJun²³,Fu Wei¹^ORCID,Liu Jinggen²³

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China

2. Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China

4. School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China

Funder

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Shanghai Science and Technology Development Foundation

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00722

Reference69 articles.

1. Respiratory Depression with Opioids

2. Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression

3. Opioid-Induced Constipation

4. Management of opioid-induced constipation

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