NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24-Reference-Cited by-同舟云学术

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NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24

Published:2022-03-31 Issue:7 Volume:65 Page:5565-5574
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Torres Felix¹,Walser Reto²^ORCID,Kaderli Janina¹,Rossi Emanuele¹,Bobby Romel²,Packer Martin J.³,Sarda Sunil²,Walker Graeme⁴,Hitchin James R.⁴,Milbradt Alexander G.²,Orts Julien¹⁵^ORCID

Affiliation:

1. Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, HCI F217, Eidgenossische Technische Hochschule Zurich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland

2. BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, United Kingdom

3. Oncology R&D, AstraZeneca, Cambridge, CB4 0WG, United Kingdom

4. Drug Discovery Unit, Cancer Research UK Manchester Institute, Alderley Park, Macclesfield SK10 4TG, United Kingdom

5. Department of Pharmaceutical Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria

Funder

AstraZeneca

Eidgen?ssische Technische Hochschule Z?rich

Universit?t Wien

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01703

Reference64 articles.

1. Role of histone acetylation in the control of gene expression

2. ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

3. ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

4. Translating the Histone Code

5. Structure and ligand of a histone acetyltransferase bromodomain

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The tripartite motif-containing 24 is a multifunctional player in human cancer;Cell & Bioscience;2024-08-19

2. Binding Mechanism of Inhibitors to BRD4 and BRD9 Decoded by Multiple Independent Molecular Dynamics Simulations and Deep Learning;Molecules;2024-04-19

3. A Benchmark Study of Protein–Fragment Complex Structure Calculations with NMR2;International Journal of Molecular Sciences;2023-09-20

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