High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes-Reference-Cited by-同舟云学术

High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes

Published:2021-07-31 Issue:15 Volume:64 Page:11379-11394
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Newman Hector¹²,Krajnc Alen³^ORCID,Bellini Dom¹,Eyermann Charles J.⁴,Boyle Grant A.⁴,Paterson Neil G.²,McAuley Katherine E.²,Lesniak Robert³,Gangar Mukesh⁴,von Delft Frank²⁵⁶⁷^ORCID,Brem Jürgen³^ORCID,Chibale Kelly⁴⁸^ORCID,Schofield Christopher J.³^ORCID,Dowson Christopher G.¹^ORCID

Affiliation:

1. School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K.

2. Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K.

3. Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K.

4. Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa

5. Structural Genomics Consortium (SGC), University of Oxford, Oxford, U.K.

6. Department of Biochemistry, University of Johannesburg, Auckland Park 2006, South Africa

7. Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, U.K.

8. South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

Funder

Medical Research Council

Global Challenges Research Fund

Diamond Light Source

Wellcome Trust

Newton Fund

University of Warwick

National Research Foundation

South African Medical Research Council

Novartis Research Foundation

Publisher

American Chemical Society (ACS)