Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography-Reference-Cited by-同舟云学术

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Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography

Published:2021-03-23 Issue:8 Volume:64 Page:4991-5000
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kneller Daniel W.¹²,Phillips Gwyndalyn¹²,Weiss Kevin L.¹²^ORCID,Zhang Qiu¹²,Coates Leighton²³^ORCID,Kovalevsky Andrey¹²^ORCID

Affiliation:

1. Neutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831, United States

2. National Virtual Biotechnology Laboratory, US Department of Energy, Washington, D.C. 20585, United States

3. Second Target Station, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831, United States

Funder

Office of Science

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00058

Reference80 articles.

1. Covid-19: a comprehensive review of a formidable foe and the road ahead

2. The novel coronavirus 2019-nCoV: Its evolution and transmission into humans causing global COVID-19 pandemic

3. COVID-19: Transmission, prevention, and potential therapeutic opportunities

4. The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

5. What Pfizer’s landmark COVID vaccine results mean for the pandemic

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