Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability-Reference-Cited by-同舟云学术

Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability

Published:2021-11-04 Issue:24 Volume:64 Page:17992-18009
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ju Han¹,Murugan N. Arul²^ORCID,Hou Lingxin¹,Li Ping³,Guizzo Laura⁴,Zhang Ying¹,Bertagnin Chiara⁴,Kong Xiujie¹,Kang Dongwei¹^ORCID,Jia Ruifang¹,Ma Xiuli⁵,Du Ruikun³,Poongavanam Vasanthanathan⁶,Loregian Arianna⁴,Huang Bing⁵,Liu Xinyong¹^ORCID,Zhan Peng¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P.R. China

2. Department of Computer Science, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm SE-10044 , Sweden

3. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China

4. Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova 35121, Italy

5. Institute of Poultry Science, Shandong Academy of Agricultural Sciences, 202 North Gongye Road, Jinan, Shandong 250100, China

6. Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense M DK-5230, Denmark

Funder

Government of Shandong Province

Shandong Academy of Agricultural Sciences

Ministero dell???Istruzione, dell???Universit?? e della Ricerca

Associazione Italiana per la Ricerca sul Cancro

Fondazione Cariparma

Taishan Scholar Project of Shandong Province

Shandong University

British Society for Antimicrobial Chemotherapy

National Natural Science Foundation of China

Shandong modern agricultural technology and industry system

Foreign cultural and educational experts Project

Science Foundation for Excellent Young Scholars of Shandong Province

Science Foundation for Outstanding Young Scholars of Shandong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01366

Reference38 articles.

1. Influenza (Seasonal); http://www.who.int/mediacentre/factsheets/fs211/en/ (accessed Oct 3, 2021).

2. Antivirals Targeting Influenza A Virus

3. Scientific barriers to developing vaccines against avian influenza viruses

4. Prospects for Broadly Protective Influenza Vaccines

5. New small-molecule drug design strategies for fighting resistant influenza A

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