Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN-Reference-Cited by-同舟云学术

Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN

Published:2021-09-15 Issue:19 Volume:64 Page:14332-14343
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chakroun Khouloud¹²,Taouai Marwa¹²,Porkolab Vanessa³,Luczkowiak Joanna⁴,Sommer Roman⁵,Cheneau Coraline⁶,Mathiron David⁷,Ben Maaouia Mohamed Amine¹²,Pilard Serge⁷,Abidi Rym²,Mullié Catherine⁸,Fieschi Franck³,Cragg Peter J.⁹,Halary Franck⁶,Delgado Rafael⁴,Benazza Mohammed¹^ORCID

Affiliation:

1. Laboratoire de Glycochimie des Antimicrobiens et des Agroressources (LG2A-UMR7378-CNRS), Université de Picardie Jules Verne, 10 Rue Baudelocque, Amiens, 80039 Cédex, France

2. Faculté des Sciences de Bizerte, Laboratoire d’Application de la Chimie aux Ressources et Substances Naturelles et à l’Environnement (LACReSNE) Unité ≪Interactions Moléculaires Spécifiques≫, Université de Carthage Zarzouna-Bizerte, Zarzouna-Bizerte, Tennessee 7021, Tunisia

3. Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, GrenobleF-38044, France

4. Laboratorio de Microbiología Molecular, Instituto de Investigación Hospital 12 de Octubre (imas12), Madrid 28041, Spain

5. Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken66123, Germany

6. Nantes Université, Inserm, CHU Nantes, Center for Research in Transplantation and Immunology UMR1064, ITUN, Nantes44093, France

7. UFR des Sciences Bâtiment Serres-Transfert Rue Dallery, Passage du sourire d’Avril, Amiens 80039 Cedex 1, France

8. Laboratoire AGIR—UR UPJV 4294, UFR de Pharmacie, Université de Picardie Jules Verne, Amiens80037, France

9. School of Pharmacy and Biomolecular Science, University of Brighton, Brighton BN2 4GJ, U.K.

Funder

???la Caixa??? Foundation

H2020 Future and Emerging Technologies

Instituto de Salud Carlos III

Conseil R??gional de Picardie

Government of Tunisia

Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources

R??gion Rh??ne-Alpes

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00818

Reference85 articles.

1. Dendritic cells in viral pathogenesis: protective or defective?

2. The Cell Surface Receptor DC-SIGN Discriminates betweenMycobacterium Species through Selective Recognition of the Mannose Caps on Lipoarabinomannan

3. Consequences of the natural propensity of Leishmania and HIV-1 to target dendritic cells

4. C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans

5. High affinity sugar ligands of C-type lectin receptor langerin

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