Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine-Reference-Cited by-同舟云学术

Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine

Published:2022-05-12 Issue:11 Volume:65 Page:7682-7696
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Malla Tika R.¹,Brewitz Lennart¹,Muntean Dorian-Gabriel¹,Aslam Hiba¹,Owen C. David²³^ORCID,Salah Eidarus¹,Tumber Anthony¹,Lukacik Petra²³,Strain-Damerell Claire²³,Mikolajek Halina²³,Walsh Martin A.²³,Schofield Christopher J.¹^ORCID

Affiliation:

1. Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, United Kingdom

2. Diamond Light Source Ltd., Harwell Science and Innovation Campus, OX11 0DE Didcot, United Kingdom

3. Research Complex at Harwell, Harwell Science and Innovation Campus, OX11 0FA Didcot, United Kingdom

Funder

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02214