Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics-Reference-Cited by-同舟云学术

Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics

Published:2021-08-23 Issue:17 Volume:64 Page:12938-12963
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gao Yongzhi¹,van Haren Matthijs J.¹^ORCID,Buijs Ned¹,Innocenti Paolo¹,Zhang Yurui¹,Sartini Davide²,Campagna Roberto²,Emanuelli Monica²,Parsons Richard B.³,Jespers Willem⁴⁵,Gutiérrez-de-Terán Hugo⁵^ORCID,van Westen Gerard J. P.⁴^ORCID,Martin Nathaniel I.¹^ORCID

Affiliation:

1. Biological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands

2. Department of Clinical Sciences, Universitá Politecnica delle Marche, Via Ranieri 65, 60131 Ancona, Italy

3. Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, United Kingdom

4. Drug Discovery and Safety, Leiden Academic Center for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands

5. Department of Cell and Molecular Biology, Uppsala University, Uppsala 75124, Sweden

Funder

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01094

Reference47 articles.

1. Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.

2. A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase

3. Nicotinamide N -Methyltransferase: More Than a Vitamin B3 Clearance Enzyme

4. Substrate specificity of nicotinamide methyltransferase isolated from porcine liver

5. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Cited by 48 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advances in the Synthesis and Physiological Metabolic Regulation of Nicotinamide Mononucleotide;Nutrients;2024-07-20

2. Adenine, a key player in biology and medicinal chemistry;Comptes Rendus. Chimie;2024-07-11

3. Discovery of a Novel ASM Direct Inhibitor with a 1,5-Diphenyl-pyrazole Scaffold and Its Antidepressant Mechanism of Action;Journal of Medicinal Chemistry;2024-06-18

4. Role of Epigenetic Modulation in Neurodegenerative Diseases: Implications of Phytochemical Interventions;Antioxidants;2024-05-15

5. Metabolic Signaling in Cancer Metastasis;Cancer Discovery;2024-03-29