Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist-Reference-Cited by-同舟云学术

Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist

Published:2021-06-14 Issue:12 Volume:64 Page:8775-8797
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wu Xishan¹²,Shen Hui¹³,Zhang Yan¹²,Wang Chao¹³,Li Qiu¹³,Zhang Cheng¹,Zhuang Xiaoxi¹,Li Chenchang¹,Shi Yudan¹,Xing Yanli¹,Xiang Qiuping¹,Xu Jinxin⁴,Wu Donghai⁴,Liu Jinsong⁵^ORCID,Xu Yong¹²⁵^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China

2. Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China

3. University of Chinese Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, China

4. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

5. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

Funder

Guangzhou Regenerative Medicine and Health Guangdong Laboratory

Ministry of Science and Technology of the People's Republic of China

China Postdoctoral Science Foundation

Chinese Academy of Sciences

Guangdong Province

Science and Technology Program of Guangzhou

Guangdong Provincial Key Laboratory of Biocomputing