Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer-Reference-Cited by-同舟云学术

Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer

Published:2021-04-15 Issue:9 Volume:64 Page:6221-6240
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bantzi Marina¹²,Augsburger Fiona²,Loup Jérémie¹,Berset Yan¹,Vasilakaki Sofia³,Myrianthopoulos Vassilios³,Mikros Emmanuel³^ORCID,Szabo Csaba²^ORCID,Bochet Christian G.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Fribourg, 1700 Fribourg, Switzerland

2. Chair of Pharmacology, Faculty of Science and Medicine University of Fribourg, 1700 Fribourg, Switzerland

3. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, 15772 Athens, Greece

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Novartis Foundation

Krebsliga Schweiz

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00260

Reference48 articles.

1. H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects

2. Physiological Roles of Hydrogen Sulfide and Polysulfides

3. International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors

4. Gasotransmitters in cancer: from pathophysiology to experimental therapy

5. Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Emerging roles of hydrogen sulfide in colorectal cancer;Chemico-Biological Interactions;2024-11

2. Role of the 3-mercaptopyruvate sulfurtransferase in colon/colorectal cancers;European Journal of Cell Biology;2024-06

3. Engineering electronic band structure of ternary thermoelectric nanocatalysts for highly efficient detection of hydrogen sulfide;Journal of Materials Chemistry A;2024

4. An Activated Structure Transformable Ratiometric Photoacoustic Nanoprobe for Real-Time Dynamic Monitoring of H₂S In Vivo;Nano Letters;2023-11-13

5. Targeting Homocysteine and Hydrogen Sulfide Balance as Future Therapeutics in Cancer Treatment;Antioxidants;2023-07-29