Novel Antiplasmodial Compounds Leveraged with Multistage Potency against the Parasite Plasmodium falciparum: In Vitro and In Vivo Evaluations and Pharmacokinetic Studies

Author:

Sharma Neha1,Kashif Mohammad2,Singh Vigyasa3,Fontinha Diana4,Mukherjee Budhaditya5,Kumar Dhruv6,Singh Shailja3ORCID,Prudencio Miguel4,Singh Agam P.2,Rathi Brijesh1ORCID

Affiliation:

1. Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi 110007, India

2. Infectious Diseases Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India

3. Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India

4. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa 1649-028, Portugal

5. School of Medical Science and Technology, IIT Kharagpur, Kharagpur 721302, India

6. Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Noida 201301, Uttar Pradesh, India

Funder

Science and Engineering Research Board

Department of Biotechnology , Ministry of Science and Technology

Council for Scientific and Industrial Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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