Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization

Author:

Qiao Zhen1,Luo Jiajie1,Tang Yi-Quan2,Zhou Qiqi3ORCID,Qi Hang1,Yin Zhengji1,Tang Xiaowen1,Zhu Wei1,Zhang Yanru14ORCID,Wei Ningning14,Wang KeWei14ORCID

Affiliation:

1. Departments of Pharmacology and Pharmaceutical Analysis, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China

2. State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China

3. Department of Pharmacology, Qilu Medical University School of Pharmacy, Zibo 255300, China

4. Institute of Innovative Drug, Qingdao University, Qingdao 266021, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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