Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold

Author:

Xiong Chaodong123,Zhou Lina13,Tan Jing123,Song Shanshan13,Bao Xubin13,Zhang Ning13,Ding Huaqian13,Zhao Jiannan124,He Jin-xue13,Miao Ze-Hong13,Zhang Ao12356ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China

2. Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

5. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China

6. State Key Laboratory of Esophageal Cancer Prevention and Treatment, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, China

Funder

Shanghai Jiao Tong University

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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