Thiazolidinedione “Magic Bullets” Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects

Author:

Tilekar Kalpana1,Hess Jessica D.2,Upadhyay Neha1,Bianco Alessandra Lo3,Schweipert Markus4,Laghezza Antonio5ORCID,Loiodice Fulvio5ORCID,Meyer-Almes Franz-Josef4ORCID,Aguilera Renato J.2,Lavecchia Antonio3ORCID,C S Ramaa1ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Navi Mumbai- 400614, India

2. Cellular Characterization and Biorepository Core Facility, Border Biomedical Research Center, Department of Biological Sciences, The University of Texas at El Paso, 500 West University Avenue, El Paso, Texas 79968, United States

3. Department of Pharmacy, “Drug Discovery” Laboratory, University of Napoli “Federico II”, Via D. Montesano, 49, 80131 Napoli, Italy

4. Department of Chemical Engineering and Biotechnology, University of Applied Science, Haardtring 100, 64295 Darmstadt, Germany

5. Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Via E. Orabona 4, 70126 Bari, Italy

Funder

Department of Science and Technology, Ministry of Science and Technology

National Institute on Minority Health and Health Disparities

State of Hesse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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