Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties-Reference-Cited by-同舟云学术

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties

Published:2021-08-10 Issue:18 Volume:64 Page:13215-13258
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vachal Petr¹,Duffy Joseph L.¹,Campeau Louis-Charles¹,Amin Rupesh P.¹,Mitra Kaushik¹,Murphy Beth Ann¹,Shao Pengcheng P.¹,Sinclair Peter J.¹,Ye Feng¹,Katipally Revathi¹,Lu Zhijian¹,Ondeyka Debra¹,Chen Yi-Heng¹,Zhao Kake¹,Sun Wanying¹,Tyagarajan Sriram¹,Bao Jianming¹,Wang Sheng-Ping¹,Cote Josee¹,Lipardi Concetta¹,Metzger Daniel¹,Leung Dennis¹,Hartmann Georgy¹,Wollenberg Gordon K.¹,Liu Jian¹,Tan Lushi¹,Xu Yingju¹,Chen Qinghao¹,Liu Guiquan²,Blaustein Robert O.¹,Johns Douglas G.¹

Affiliation:

1. Merck & Co., Inc., 2000 Galloping Hill Rd., Kenilworth, New Jersey 07033, United States

2. WuXi AppTec, 90 Delin Rd., Waigaoqiao Free Trade Zone, Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00959

Reference71 articles.

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3. Lipoprotein(a) as a cardiovascular risk factor: current status

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5. Association of LDL Cholesterol, Non–HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins

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