Polycomb Repressive Complex 2 Modulation through the Development of EZH2–EED Interaction Inhibitors and EED Binders
Author:
Affiliation:
1. Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, 80131 Naples, Italy
2. Department of Chemistry and Technology of Drugs, “Sapienza” University of Rome, P.le A. Moro 5, 00185 Rome, Italy
Funder
Ministero dell???Istruzione, dell???Universit?? e della Ricerca
Sapienza Universit?? di Roma
Associazione Italiana per la Ricerca sul Cancro
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00226
Reference95 articles.
1. Genome Regulation by Polycomb and Trithorax: 70 Years and Counting
2. The Polycomb complex PRC2 and its mark in life
3. Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
4. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase
5. Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cited by 30 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities;PLOS Neglected Tropical Diseases;2024-09-05
2. Dynamic changes in the proximitome of neutral sphingomyelinase-2 (nSMase2) in TNFα stimulated Jurkat cells;Frontiers in Immunology;2024-07-09
3. Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy;Cancer Discovery;2024-06-03
4. Targeting EED as a key PRC2 complex mediator toward novel epigenetic therapeutics;Drug Discovery Today;2024-06
5. EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy;Scientific Reports;2024-04-04
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3