Iterative Optimization and Structure–Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors <i>via</i> Targeting 150-Cavity-Reference-Cited by-同舟云学术

Iterative Optimization and Structure–Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity

Published:2022-08-08 Issue:17 Volume:65 Page:11550-11573
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ju Han¹,Hou Lingxin¹,Zhao Fabao¹^ORCID,Zhang Ying¹,Jia Ruifang¹,Guizzo Laura²,Bonomini Anna²,Zhang Jiwei¹,Gao Zhen¹,Liang Ruipeng¹,Bertagnin Chiara²,Kong Xiujie¹,Ma Xiuli³,Kang Dongwei¹,Loregian Arianna²,Huang Bing³,Liu Xinyong¹^ORCID,Zhan Peng¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P. R. China

2. Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy

3. Institute of Poultry Science, Shandong Academy of Agricultural Sciences, 202 North Gongye Road, 250100 Jinan, Shandong, P. R. China

Funder

Shandong Province

Shandong Academy of Agricultural Sciences

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Associazione Italiana per la Ricerca sul Cancro

Taishan Scholar Project of Shandong Province

Shandong University

British Society for Antimicrobial Chemotherapy

National Natural Science Foundation of China

Fondazione Cassa di Risparmio di Padova e Rovigo - Bando Ricerc