Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors-Reference-Cited by-同舟云学术

Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors

Published:2022-06-03 Issue:12 Volume:65 Page:8169-8190
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Davis Owen A.¹,Cheung Kwai-Ming J.¹,Brennan Alfie¹,Lloyd Matthew G.¹^ORCID,Rodrigues Matthew J.¹²,Pierrat Olivier A.¹,Collie Gavin W.¹²^ORCID,Le Bihan Yann-Vaï¹²^ORCID,Huckvale Rosemary¹,Harnden Alice C.¹^ORCID,Varela Ana¹,Bright Michael D.¹,Eve Paul¹,Hayes Angela¹,Henley Alan T.¹,Carter Michael D.¹,McAndrew P. Craig¹,Talbot Rachel¹,Burke Rosemary¹,van Montfort Rob L. M.¹²,Raynaud Florence I.¹^ORCID,Rossanese Olivia W.¹,Meniconi Mirco¹^ORCID,Bellenie Benjamin R.¹^ORCID,Hoelder Swen¹^ORCID

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K..

2. Division of Structural Biology, The Institute of Cancer Research, London SM2 5NG, U.K..

Funder

Cancer Research UK

Sixth Element Capital

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02174