Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors
Author:
Affiliation:
1. Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K..
2. Division of Structural Biology, The Institute of Cancer Research, London SM2 5NG, U.K..
Funder
Cancer Research UK
Sixth Element Capital
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02174
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1. The Transcriptional Regulation of Germinal Center Formation
2. Roles of BCL6 in normal and transformed germinal center B cells
3. The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis
4. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
5. Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer
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