AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2-Reference-Cited by-同舟云学术

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2

Published:2021-08-31 Issue:18 Volume:64 Page:13807-13829
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Narjes Frank^ORCID,Llinas Antonio^ORCID,von Berg Stefan,Jirholt Johan,Lever Sarah,Pehrson Rikard,Collins Mia,Malmberg Anna,Svanberg Petter,Xue Yafeng¹,Olsson Roine I.,Malmberg Jesper,Hughes Glyn,Hossain Nafizal,Grindebacke Hanna,Leffler Agnes,Krutrök Nina,Bäck Elisabeth,Ramnegård Marie,Lepistö Matti,Thunberg Linda²,Aagaard Anna¹,McPheat Jane¹,Hansson Eva L.¹,Chen Rongfeng³,Xiong Yao³,Hansson Thomas G.

Affiliation:

1. Mechanistic & Structural Biology, Discovery Science, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden

2. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden

3. Pharmaron Beijing Co., Ltd., Taihe Road BDA, Beijing 100176, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01197

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1. Interleukin-17 and innate immunity in infections and chronic inflammation