Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression-Reference-Cited by-同舟云学术

Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression

Published:2021-12-13 Issue:24 Volume:64 Page:18158-18174
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Damalanka Vishnu C.¹,Voss Jorine J. L. P.¹,Mahoney Matthew W.²,Primeau Tina³,Li Shunqiang³,Klampfer Lidija²,Janetka James W.¹²^ORCID

Affiliation:

1. Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri 63110, United States

2. ProteXase Therapeutics, Inc., Saint Louis, Missouri 63108, United States

3. Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, United States

Funder

National Cancer Institute

Foundation for Barnes-Jewish Hospital

Alvin J. Siteman Cancer Center

School of Medicine, Washington University in St. Louis

BioSTL

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01671

Reference80 articles.

1. Cancer statistics, 2020

2. Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights

MET Oncogene in Non-Small Cell Lung Cancer: Mechanism of MET Dysregulation and Agents Targeting the HGF/c-Met Axis

4. Incidence of EGFR Exon 19 Deletions and L858R in Tumor Specimens From Men and Cigarette Smokers With Lung Adenocarcinomas

5. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer

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