Structural Optimization and Structure–Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants-Reference-Cited by-同舟云学术

Structural Optimization and Structure–Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

Published:2022-01-26 Issue:3 Volume:65 Page:2035-2058
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pan Shulei¹,Zhang Liting¹,Luo Xinling²,Nan Jinshan¹,Yang Wei¹,Bin Huachao¹,Li Yang¹,Huang Qiao²,Wang Tianqi¹,Pan Zhiling¹,Mu Bo¹,Wang Falu¹,Tian Chenyu²,Liu Yang¹,Li Linli²,Yang Shengyong¹^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

2. Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China

Funder

Sichuan University

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Sichuan Province

West China Hospital, Sichuan University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01597