Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior-Reference-Cited by-同舟云学术

Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior

Published:2021-12-20 Issue:1 Volume:65 Page:257-270
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nguyen Thuy¹^ORCID,Gamage Thomas F.¹,Finlay David B.²^ORCID,Decker Ann M.¹^ORCID,Langston Tiffany L.¹,Barrus Daniel¹,Glass Michelle²^ORCID,Li Jun-Xu³^ORCID,Kenakin Terry P.⁴,Zhang Yanan¹^ORCID

Affiliation:

1. Research Triangle Institute, Research Triangle Park, Research Triangle Park, North Carolina 27709, United States

2. Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand

3. Department of Pharmacology and Toxicology, University at Buffalo, the State University of New York, Buffalo, New York 14214, United States

4. Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, United States

Funder

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01432

Reference49 articles.

1. Center for Behavioral Health Statistics and Quality. Behavioral Health Trends in the United States: Results from the 2014 National Survey on Drug Use and Health; Substance Abuse and Mental Health Services Administration, 2015.

2. CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS

3. Cannabinoid physiology and pharmacology: 30 years of progress

4. Endocannabinoids New Targets for Drug Development

5. Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area

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