N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y4 Receptor Ligands Results in Picomolar Binding Constants-Reference-Cited by-同舟云学术

N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y4 Receptor Ligands Results in Picomolar Binding Constants

Published:2021-11-08 Issue:22 Volume:64 Page:16746-16769
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Konieczny Adam¹,Conrad Marcus²^ORCID,Ertl Fabian J.¹^ORCID,Gleixner Jakob¹,Gattor Albert O.¹^ORCID,Grätz Lukas¹^ORCID,Schmidt Maximilian F.³^ORCID,Neu Eduard⁴^ORCID,Horn Anselm H. C.²^ORCID,Wifling David¹,Gmeiner Peter³^ORCID,Clark Timothy³⁴^ORCID,Sticht Heinrich²^ORCID,Keller Max¹^ORCID

Affiliation:

1. Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany

2. Institute of Biochemistry, Emil-Fischer-Center, Friedrich-Alexander-University Erlangen-Nürnberg, Fahrstraße 17, D-91054 Erlangen, Germany

3. Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, D-91058 Erlangen, Germany

4. Department of Chemistry and Pharmacy, Computer-Chemistry-Center, Friedrich-Alexander-University Erlangen-Nürnberg, Nägelsbachstraße 25, D-91052 Erlangen, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01574

Reference59 articles.

1. Cloning and Functional Expression of a Human Y4 Subtype Receptor for Pancreatic Polypeptide, Neuropeptide Y, and Peptide YY

2. Structure-affinity studies of C-terminally modified analogs of neuropeptide Y led to a novel class of peptidic Y1 receptor antagonist

3. Pancreatic Polypeptide Is Recognized by Two Hydrophobic Domains of the Human Y4 Receptor Binding Pocket

4. Elucidation of the Binding Mode of the Carboxyterminal Region of Peptide YY to the Human Y2 Receptor

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