Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult-Reference-Cited by-同舟云学术

Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult

Published:2021-06-07 Issue:12 Volume:64 Page:8333-8353
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gornati Davide¹,Ciccone Roselia²,Vinciguerra Antonio²,Ippati Stefania³,Pannaccione Anna²,Petrozziello Tiziana²,Pizzi Erika³,Hassan Amal⁴,Colombo Eleonora¹,Barbini Stefano¹,Milani Mario⁴,Caccavone Cecilia³,Randazzo Pietro⁵,Muzio Luca⁶,Annunziato Lucio⁷,Menegon Andrea³,Secondo Agnese²,Mastrangelo Eloise⁴^ORCID,Pignataro Giuseppe²,Seneci Pierfausto¹^ORCID

Affiliation:

1. Chemistry Department, University of Milan, Via Golgi 19, 20133 Milan, Italy

2. Division of Pharmacology, Department of Neuroscience, School of Medicine, University of Naples Federico II, Via Pansini 5, I-80131 Naples, Italy

3. Experimental Imaging Center, ALEMBIC—Advanced Light and Electron Microscopy BioImaging Center, San Raffaele Scientific Institute, Via Olgettina 60, I-20132 Milan, Italy

4. National Research Council-Biophysics Institute (CNR-IBF), and Biosciences Department University of Milan, Via Celoria, 26, I-20133 Milan, Italy

5. Promidis srl, Via Olgettina 60, I-20132 Milan, Italy

6. INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute, Via Olgettina 60, I-20132 Milan, Italy

7. IRCCS SDN, Via E. Gianturco 113, 80143 Naples, Italy

Funder

Ministero dell???Istruzione, dell???Universit?? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00305