3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents

Author:

Konno Sho1,Kobayashi Kiyotaka1,Senda Miki2ORCID,Funai Yuta3,Seki Yuta3,Tamai Ikumi3ORCID,Schäkel Laura4,Sakata Kyousuke5,Pillaiyar Thanigaimalai6,Taguchi Akihiro1,Taniguchi Atsuhiko1,Gütschow Michael4ORCID,Müller Christa E.4ORCID,Takeuchi Koh7ORCID,Hirohama Mikako8,Kawaguchi Atsushi8,Kojima Masaki5,Senda Toshiya2,Shirasaka Yoshiyuki3,Kamitani Wataru9,Hayashi Yoshio1ORCID

Affiliation:

1. School of Pharmacy, Department of Medicinal Chemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan

2. Structural Biology Research Center, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba 305-0801, Japan

3. Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan

4. Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53121, Germany

5. School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan

6. Pharmaceutical Institute, Pharmaceutical/Medicinal Chemistry, University of Tübingen, Tübingen 72076, Germany

7. Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Koto, Tokyo 135-0064, Japan

8. Faculty of Medicine, Transborder Medical Research Center, University of Tsukuba, Tsukuba 305-8575, Japan

9. Department of Infectious Diseases and Host Defense, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan

Funder

Core Research for Evolutional Science and Technology

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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