Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity-Reference-Cited by-同舟云学术

Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity

Published:2022-02-20 Issue:5 Volume:65 Page:4085-4120
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Verma Vishal A.¹^ORCID,Wang Lan¹,Labadie Sharada S.¹,Liang Jun¹^ORCID,Sellers Benjamin D.¹^ORCID,Wang Jian²,Dong Liting²,Wang Qiuyue²,Zhang Shuang²,Xu Zhongya²,Zhang Yexia²,Niu Yanan²,Wang Xinxin²,Wai John²,Koehler Michael F. T.¹,Hu Huiyong¹,Alexander Mary Kate¹,Nishiyama Mireille¹,Miu Anh¹,Xu Yiming¹,Pang Jodie¹,Katakam Anand K.¹,Reichelt Michael¹,Austin Cary D.¹,Ho Hoangdung¹,Payandeh Jian¹,Koth Christopher M.¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People’s Republic of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01909

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