Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA)-Reference-Cited by-同舟云学术

Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA)

Published:2021-12-13 Issue:3 Volume:65 Page:1933-1945
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

S El Salamouni Nehad¹²³,Buckley Benjamin J.¹²³⁴,Jiang Longguang⁵^ORCID,Huang Mingdong⁵^ORCID,Ranson Marie¹²³⁴,Kelso Michael J.¹²³^ORCID,Yu Haibo¹²³^ORCID

Affiliation:

1. School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia

2. Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia

3. Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia

4. CONCERT-Translational Cancer Research Centre, Sydney, NSW 2750, Australia

5. National Joint Biomedical Engineering Research Centre on Photodynamic Technologies, Fuzhou University, Fujian 350116, China

Funder

University of Wollongong

Department of Health, Australian Government

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01423

Reference94 articles.

1. The plasminogen activation system in tumor growth, invasion, and metastasis

2. The Urokinase Plasminogen Activator System: A Target for Anti-Cancer Therapy

3. Angiogenesis in Health, Disease and Malignancy

4. Revisiting the biological roles of PAI2 (SERPINB2) in cancer

5. The urokinase plasminogen activator system: a rich source of tumour markers for the individualised management of patients with cancer

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