Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment

Published:2021-12-14 Issue:24 Volume:64 Page:18175-18192
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Chungen¹,Yang Xiaowei²,Luo Yuan¹,Liu Huan²,Zhong Xi²,Zhou Xia¹,Zeng Ting¹,Tao Lei¹,Zhou Yue¹,Gou Kun¹,Yang Xinyu¹,Liu Xiaocong¹,Chen Qiang¹,Zhao Yinglan¹²,Luo Youfu¹^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

2. Department of Pharmacology, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01711

Reference58 articles.

1. Mammalian Pyrimidine Biosynthesis: Fresh Insights into an Ancient Pathway

2. Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy