Discovery, Optimization, and Evaluation of Quinazolinone Derivatives with Novel Linkers as Orally Efficacious Phosphoinositide-3-Kinase Delta Inhibitors for Treatment of Inflammatory Diseases-Reference-Cited by-同舟云学术

Discovery, Optimization, and Evaluation of Quinazolinone Derivatives with Novel Linkers as Orally Efficacious Phosphoinositide-3-Kinase Delta Inhibitors for Treatment of Inflammatory Diseases

Published:2021-06-17 Issue:13 Volume:64 Page:8951-8970
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Kongjun¹,Li Dan¹,Zheng Wei¹,Shi Mingsong¹,Chen Yong¹,Tang Minghai¹,Yang Tao¹,Zhao Min¹^ORCID,Deng Dexin¹,Zhang Chufeng¹,Liu Jiang¹,Yuan Xue¹,Yang Zhuang¹²,Chen Lijuan¹²^ORCID

Affiliation:

1. Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China

2. Chengdu Zenitar Biomedical Technology Co., Ltd., Chengdu 610041, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

West China Hospital, Sichuan University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00004

Reference61 articles.